Last update
9/29/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Lactobacillus acidophilus (La-14)
2 Billion CFU
*
Top Medical Research Studies
8
Probiotics help rheumatoid arthritis symptoms
This study explored how probiotic supplementation affects patients with rheumatoid arthritis (RA) over eight weeks.
We analyzed the results from sixty patients, split into groups receiving either probiotics or placebo.
The findings showed that those taking probiotics experienced a notable improvement in joint health, as well as reductions in insulin levels and inflammation markers.
We observed that the probiotics had a positive impact on overall metabolic health, significantly benefitting those with RA.
We analyzed the results from sixty patients, split into groups receiving either probiotics or placebo.
The findings showed that those taking probiotics experienced a notable improvement in joint health, as well as reductions in insulin levels and inflammation markers.
We observed that the probiotics had a positive impact on overall metabolic health, significantly benefitting those with RA.
Read More
8
This study looked at how probiotics help reduce oral candidiasis in Sjögren's syndrome patients. We divided 32 participants into two groups: one received probiotics, while the other got a placebo for five weeks.
By the end of the trial, those taking probiotics showed a significant decrease in candidal growth, unlike the placebo group who did not see any notable change. This suggests that probiotics could be a promising alternative for preventing oral thrush in these patients.
By the end of the trial, those taking probiotics showed a significant decrease in candidal growth, unlike the placebo group who did not see any notable change. This suggests that probiotics could be a promising alternative for preventing oral thrush in these patients.
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8
We examined the role of probiotics in managing systemic lupus erythematosus (SLE) using various mouse models. Through a systematic review of 12 studies, we found that certain probiotic strains, including L. acidophilus, significantly decreased levels of inflammatory markers while boosting anti-inflammatory responses.
These positive changes led to longer periods of remission and a reduction in disease flare-ups. However, although these results are promising, more human clinical trials are needed to fully understand the safety and effectiveness of probiotics for SLE.
These positive changes led to longer periods of remission and a reduction in disease flare-ups. However, although these results are promising, more human clinical trials are needed to fully understand the safety and effectiveness of probiotics for SLE.
Read More
Most Useful Reviews
9
Gut health improvement
2 people found this helpful
This product has really helped settle my children's gut issues, especially when taken on an empty stomach. After finishing the last capsule, I'm ordering two more containers.
Read More
7.5
Supports health resilience
1 people found this helpful
Now Foods provides a sustainable probiotic that has maintained our health despite my husband's Crohn's Disease and my autoimmune disorder. We've been using it for several months.
Read More
8
Digestive support noted
1 people found this helpful
This high-quality supplement has been beneficial for my digestion and has alleviated constipation, making it a great help for my autoimmune disorder and other digestive issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8
- All Researches
9
We investigated the effects of combining lactic acid (LA) with Tacrolimus (Tac) on treating lupus in mice. By administering both treatments, we observed an improvement in gut health and a balanced ratio of T cell subsets.
The combination therapy significantly decreased harmful autoantibody levels and improved kidney health. Additionally, it boosted regulatory T (Treg) cells while reducing T helper 17 (Th17) cells, ultimately enhancing the effectiveness of Tac for managing lupus-like conditions.
The combination therapy significantly decreased harmful autoantibody levels and improved kidney health. Additionally, it boosted regulatory T (Treg) cells while reducing T helper 17 (Th17) cells, ultimately enhancing the effectiveness of Tac for managing lupus-like conditions.
Read More
9
We assessed how Lactobacillus casei, a type of probiotic bacteria, impacted autoimmune responses in rats with rheumatoid arthritis. The treatment showed promise, significantly reducing joint swelling and preventing bone destruction by restoring the gut microbiome.
The analysis revealed that L. casei not only helped correct microbiome imbalances but also lowered inflammation indicators. Though these results are promising, further investigation is needed to confirm the effectiveness of probiotics in human arthritis treatment.
The analysis revealed that L. casei not only helped correct microbiome imbalances but also lowered inflammation indicators. Though these results are promising, further investigation is needed to confirm the effectiveness of probiotics in human arthritis treatment.
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9
Synbiotics improve rheumatoid arthritis outcomes
We examined how synbiotic supplementation impacts patients with rheumatoid arthritis over 8 weeks. In our double-blind, placebo-controlled trial involving 54 participants, we found that those taking synbiotics experienced significant improvements. These included lower inflammation markers such as hs-CRP and better joint pain scores on the DAS-28 and VAS.
Additionally, improvements were noted in insulin resistance and oxidative stress markers, hinting at potential metabolic benefits. Overall, our findings suggest that synbiotic treatment could play a role in managing some aspects of rheumatoid arthritis effectively.
Additionally, improvements were noted in insulin resistance and oxidative stress markers, hinting at potential metabolic benefits. Overall, our findings suggest that synbiotic treatment could play a role in managing some aspects of rheumatoid arthritis effectively.
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9
We examined how a special probiotic mix, known as IRT5, affects autoimmune diabetes in non-obese diabetic (NOD) mice. Administered frequently over 36 weeks, this combination not only reduced diabetes incidence but also lowered insulitis scores and increased insulin-producing β-cell mass.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
Additionally, IRT5 improved gut health and changed the makeup of immune cells in the pancreas and intestines. While some immune responses stayed the same, the shift towards more gut-focused regulatory T cells suggests it could be a promising treatment for type 1 diabetes.
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8
We assessed the potential benefits of synbiotics on inflammation in patients with systemic lupus erythematosus (SLE), an autoimmune condition impacting various organs. In a randomized, double-blind trial, 50 participants received either standard treatment with synbiotics or standard treatment alone for two months.
Remarkably, those on synbiotics showed significant reductions in inflammatory markers and SLE activity scores, while the placebo group showed no substantial changes. This suggests that synbiotics might serve as a helpful additional therapy for SLE management. However, more research is needed to understand how this works.
Remarkably, those on synbiotics showed significant reductions in inflammatory markers and SLE activity scores, while the placebo group showed no substantial changes. This suggests that synbiotics might serve as a helpful additional therapy for SLE management. However, more research is needed to understand how this works.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Gut health improvement
2 people found this helpful
This product has really helped settle my children's gut issues, especially when taken on an empty stomach. After finishing the last capsule, I'm ordering two more containers.
Read More
7.5
Supports health resilience
1 people found this helpful
Now Foods provides a sustainable probiotic that has maintained our health despite my husband's Crohn's Disease and my autoimmune disorder. We've been using it for several months.
Read More
8
Digestive support noted
1 people found this helpful
This high-quality supplement has been beneficial for my digestion and has alleviated constipation, making it a great help for my autoimmune disorder and other digestive issues.
Read More
Frequently Asked Questions
7.5
Supports health resilience
1 people found this helpful
Now Foods provides a sustainable probiotic that has maintained our health despite my husband's Crohn's Disease and my autoimmune disorder. We've been using it for several months.
9
Gut health improvement
2 people found this helpful
This product has really helped settle my children's gut issues, especially when taken on an empty stomach. After finishing the last capsule, I'm ordering two more containers.
8
Digestive support noted
1 people found this helpful
This high-quality supplement has been beneficial for my digestion and has alleviated constipation, making it a great help for my autoimmune disorder and other digestive issues.
8
We assessed the potential benefits of synbiotics on inflammation in patients with systemic lupus erythematosus (SLE), an autoimmune condition impacting various organs. In a randomized, double-blind trial, 50 participants received either standard treatment with synbiotics or standard treatment alone for two months.
Remarkably, those on synbiotics showed significant reductions in inflammatory markers and SLE activity scores, while the placebo group showed no substantial changes. This suggests that synbiotics might serve as a helpful additional therapy for SLE management. However, more research is needed to understand how this works.
Remarkably, those on synbiotics showed significant reductions in inflammatory markers and SLE activity scores, while the placebo group showed no substantial changes. This suggests that synbiotics might serve as a helpful additional therapy for SLE management. However, more research is needed to understand how this works.
7
We investigated how Lactobacillus acidophilus and propionate may influence Sjögren's syndrome, an autoimmune disorder affecting glands. By studying mice over 24 weeks, we recorded changes in saliva production and examined their salivary glands.
Our findings indicate that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome. Specifically, it enhanced beneficial bacteria that produce propionate, which in turn helped regulate the STIM1-STING signaling pathway involved in the disease.
Therefore, Lactobacillus acidophilus, alongside propionate, shows promise as a therapeutic option for Sjögren's syndrome.
Our findings indicate that Lactobacillus acidophilus improved symptoms of Sjögren's syndrome. Specifically, it enhanced beneficial bacteria that produce propionate, which in turn helped regulate the STIM1-STING signaling pathway involved in the disease.
Therefore, Lactobacillus acidophilus, alongside propionate, shows promise as a therapeutic option for Sjögren's syndrome.
9
We investigated the effects of combining lactic acid (LA) with Tacrolimus (Tac) on treating lupus in mice. By administering both treatments, we observed an improvement in gut health and a balanced ratio of T cell subsets.
The combination therapy significantly decreased harmful autoantibody levels and improved kidney health. Additionally, it boosted regulatory T (Treg) cells while reducing T helper 17 (Th17) cells, ultimately enhancing the effectiveness of Tac for managing lupus-like conditions.
The combination therapy significantly decreased harmful autoantibody levels and improved kidney health. Additionally, it boosted regulatory T (Treg) cells while reducing T helper 17 (Th17) cells, ultimately enhancing the effectiveness of Tac for managing lupus-like conditions.
7
Probiotics reduce RA inflammation markers
We investigated how a mix of probiotics affects inflammation in individuals with rheumatoid arthritis (RA). In a rigorously designed 60-day study, 42 participants were split into two groups, one receiving probiotics and the other a placebo.
The results showed a notable drop in certain inflammatory markers in the probiotic group, including white blood cells and specific cytokines. Furthermore, they exhibited improvements in oxidative stress indicators. However, not all measured factors showed significant differences, indicating that while probiotics can help, their full impact on RA may vary.
The results showed a notable drop in certain inflammatory markers in the probiotic group, including white blood cells and specific cytokines. Furthermore, they exhibited improvements in oxidative stress indicators. However, not all measured factors showed significant differences, indicating that while probiotics can help, their full impact on RA may vary.
7
Probiotics show mixed results in MS
We explored how probiotic supplementation affects gene expression related to inflammation and lipids in patients with multiple sclerosis (MS). In a 12-week, randomized, controlled trial, 40 participants received either a probiotic blend or a placebo.
While we did observe significant down-regulation of genes for inflammation markers IL-8 and TNF-α, the treatment didn't affect other genes like IL-1 or LDLR. This suggests probiotics may have some benefits in managing inflammation among MS patients, but more research is needed to clarify their overall role.
While we did observe significant down-regulation of genes for inflammation markers IL-8 and TNF-α, the treatment didn't affect other genes like IL-1 or LDLR. This suggests probiotics may have some benefits in managing inflammation among MS patients, but more research is needed to clarify their overall role.
References
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Goh RC, Maharajan MK, Gopinath D, Fang CM. The Therapeutic Effects of Probiotic on Systemic Lupus Erythematosus in Lupus Mice Models: A Systematic Review. Probiotics Antimicrob Proteins. 2025;17:35. 10.1007/s12602-024-10297-1
- Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, et al. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023;21:135. 10.1186/s12964-023-01141-0
- Kim DS, Park Y, Choi JW, Park SH, Cho ML, et al. Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice the SIGNR3 Pathway. Front Immunol. 2021;12:696074. 10.3389/fimmu.2021.696074
- Cannarella LAT, Mari NL, Alcântara CC, Iryioda TMV, Costa NT, et al. Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis. Nutrition. 2021;89:111282. 10.1016/j.nut.2021.111282
- Kamal Y, Kandil M, Eissa M, Yousef R, Elsaadany B. Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. Rheumatol Int. 2020;40:873. 10.1007/s00296-020-04558-9
- Pan H, Guo R, Ju Y, Wang Q, Zhu J, et al. A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis. Microbiome. 2019;7:107. 10.1186/s40168-019-0719-1
- Tamtaji OR, Kouchaki E, Salami M, Aghadavod E, Akbari E, et al. The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Coll Nutr. 2017;36:660. 10.1080/07315724.2017.1347074
- Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095. 10.1017/S000711451700085X
- Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869. 10.1111/1756-185X.12888
- Bleau C, Lamontagne L, Savard R. New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol. 2005;140:427.
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Kim TK, Lee JC, Im SH, Lee MS. Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics. Front Immunol. 2020;11:1832. 10.3389/fimmu.2020.01832
- Kim J, Choi SH, Kim YJ, Jeong HJ, Ryu JS, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9. 10.3390/nu9111166
